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| Rodrigues, Alice M. S.; Eparvier, Veronique; Odonne, Guillaume; Amusant, Nadine; Stien, Didier; Houel, Emeline. |
| Mankind is on the verge of a postantibiotic era. New concepts are needed in our battle to attenuate infectious diseases around the world and broad spectrum plant-inspired synergistic pharmaceutical preparations should find their place in the global fight against pathogenic microorganisms. To progress towards the discovery of potent antifungal agents against human pathologies, we embarked upon developing chemometric approach coupled with statistical design to unravel the origin of the anticandidal potential of a set of 66 essential oils (EOs). EOs were analyzed by GC-MS and tested against Candida albicans and C. parapsilosis (Minimal Inhibitory Concentration, MIC). An Orthogonal Partial Least Square (OPLS) analysis allowed us to identify six molecules... |
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| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00505/61647/65570.pdf |
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| Falkowski, Michaël; Jahn-oyac, Arnaud; Odonne, Guillaume; Flora, Claudiane; Estevez, Yannick; Touré, Seindé; Boulogne, Isabelle; Robinson, Jean-charles; Béreau, Didier; Petit, Philippe; Azam, Didier; Coke, Maïra; Issaly, Jean; Gaborit, Pascal; Stien, Didier; Eparvier, Véronique; Dusfour, Isabelle; Houël, Emeline. |
| Natural products have proven to be an immeasurable source of bioactive compounds. The exceptional biodiversity encountered in Amazonia, alongside a rich entomofauna and frequent interactions with various herbivores is the crucible of a promising chemodiversity. This prompted us to search for novel botanical insecticides in French Guiana. As this French overseas department faces severe issues linked to insects, notably the strong incidence of vector-borne infectious diseases, we decided to focus our research on products able to control the mosquito Aedes aegypti. We tested 452 extracts obtained from 85 species originating from 36 botanical families and collected in contrasted environments against an Aedes aegypti laboratory strain susceptible to all... |
| Tipo: Text |
Palavras-chave: Mosquito larvicides; Culicidae; Amazonian chemodiversity; Screening optimization; Quasi-Poisson generalized linear model; Chemical defense. |
| Ano: 2020 |
URL: https://archimer.ifremer.fr/doc/00514/62544/66894.pdf |
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