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Selection of Vibrio crassostreae relies on a plasmid expressing a type 6 secretion system cytotoxic for host immune cells ArchiMer
Piel, Damien; Bruto, Maxime; James, Adele; Labreuche, Yannick; Lambert, Christophe; Janicot, Adrian; Chenivesse, Sabine; Petton, Bruno; Wegner, K. Mathias; Stoudmann, Candice; Blokesch, Melanie; Le Roux, Frederique.
Pacific oyster mortality syndrome affects juveniles of Crassostrea gigas oysters and threatens the sustainability of commercial and natural stocks of this species. Vibrio crassostreae has been repeatedly isolated from diseased animals and the majority of the strains have been demonstrated to be virulent for oysters. In this study we showed that oyster farms exhibited a high prevalence of a virulence plasmid carried by V. crassostreae while oysters, at an adult stage, were reservoirs of this virulent population. The pathogenicity of V. crassostreae depends on a novel transcriptional regulator, which activates the bidirectional promoter of a Type 6 Secretion System (T6SS) genes cluster. Both the T6SS and a second chromosomal virulence factor, r5.7, are...
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Ano: 2020 URL: https://archimer.ifremer.fr/doc/00510/62129/66343.pdf
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