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	Provedor de dados BJMBR (1) Autor Aschner,M. (1) Farina,M. (1) Rocha,J.B.T. (1) Souza,D.O. (1) Syversen,T. (1) Palavra-chave Astrocytes (1) Glutamate and selenocompounds (1) Methylmercury neurotoxicity (1) Oxidative stress (1) Reactive oxygen species (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2007 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity BJMBR Aschner,M.; Syversen,T.; Souza,D.O.; Rocha,J.B.T.; Farina,M.. This review addresses the mechanisms of methylmercury (MeHg)-induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings point to a central role for astrocytes in mediating MeHg-induced neurotoxicity as evidenced by the following observations: a) MeHg preferentially accumulates in astrocytes; b) MeHg specifically inhibits glutamate uptake in astrocytes; c) neuronal dysfunction is secondary to disturbances in astrocytes. The generation of reactive oxygen species (ROS) by MeHg has been observed in various experimental paradigms. For example, MeHg enhances ROS formation both in vivo (rodent cerebellum) and in vitro (isolated rat brain synaptosomes), as well as in neuronal and mixed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Methylmercury neurotoxicity; Oxidative stress; Glutamate and selenocompounds; Reactive oxygen species; Astrocytes. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300001 Registros recuperados: 1 Primeira ... 1 ... Última

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