| The discussion will focus on the role of the ribosomal protein S6 kinase (S6K) signaling pathway in the regulation of cell growth and proliferation. Although 40S ribosomal protein S6 phosphorylation was first described 25 years ago (<A HREF="#20">Gressner and Wool, 1974</A>), it only recently has been implicated in the translational up-regulation of mRNAs coding for the components of protein synthetic apparatus (<A HREF="#15">Fumagalli and Thomas, 2000</A>). These mRNAs contain an oligopyrimidine tract at their 5' transcriptional start site, termed a 5'TOP, which has been shown to be essential for their regulation at the translational level (<A HREF="#32">Meyuhas et al., 1996</A>). In parallel, a great deal of... |
