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	Provedor de dados Genet. Mol. Biol. (5) Autor Takahashi,Catarina Satie (5) Antunes,Lusânia Maria Greggi (2) Antonucci,Gilmara Ausech (1) Araújo,Maria Cristina Paiva (1) Beleboni,Rene Oliveira (1) Colnaghi,Vanessa (1) Dias,Francisca da Luz (1) Fachin,Ana Lúcia (1) Ferreira,Luis Eduardo (1) Franchi,Leonardo Pereira (1) Gusmão,Cássia Lima Silva (1) Leite-Silva,Cleide (1) Marins,Mozart (1) Martins,Juliana Simões (1) Pereira,Paulo Sérgio (1) Rizo,Walace Fraga (1) Mais... Palavra-chave Chromosomal aberrations (3) Comet assay (2) 2-CdA (1) 3T3 (1) Antigenotoxicity (1) Apoptosis (1) CHO (1) Cell cycle (1) Curcumin (1) Doxorubicin (1) Fucus vesiculosus (1) Human lymphocytes (1) Hydrogen peroxide (1) Indole alkaloid (1) LDH (1) Mutagenesis (1) SCE (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Info:eu-repo/semantics/other (1) Ano 2013 (1) 2007 (1) 2005 (2) 1999 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Genotoxic and antigenotoxic effects of Fucus vesiculosus extract on cultured human lymphocytes using the chromosome aberration and Comet assays Genet. Mol. Biol. Leite-Silva,Cleide; Gusmão,Cássia Lima Silva; Takahashi,Catarina Satie. The brown seaweed Fucus vesiculosus (Fucales, Fucaceae) was screened for its protective activity using doxorubicin-induced DNA damage in human lymphocytes. In this study, we assessed the genotoxic and antigenotoxic potential of three different concentrations (0.25, 0.5 and 1.0 mg mL-1) of F. vesiculosus aqueous extract using the chromosome aberration and Comet assays. Treatment of human lymphocyte cultures with 0.25, 0.5 and 1.0 mg mL-1 F. vesiculosus aqueous extract had no effect on the chromosome aberration frequency or on the extent of DNA damage detected by the Comet assay. The antigenotoxic effects of the extract were tested in human lymphocyte cultures treated with 15 µg mL-1 of doxorubicin, either alone or combined with the different concentrations... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antigenotoxicity; Chromosomal aberrations; Comet assay; Doxorubicin; Fucus vesiculosus. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000100019 Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells Genet. Mol. Biol. Antunes,Lusânia Maria Greggi; Araújo,Maria Cristina Paiva; Dias,Francisca da Luz; Takahashi,Catarina Satie. The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Curcumin combined with H2O2 did not increase the chromosomal aberrations more than expected based on a simple additive effect. In contrast, the combination of curcumin-Fe significantly decreased the total number of chromosomal aberrations and the number of abnormal metaphases. The clastogenicity of curcumin may be related to its pro-oxidant properties and its ability to generate free radicals. Tipo: Info:eu-repo/semantics/article Palavras-chave: CHO; Chromosomal aberrations; Curcumin; Hydrogen peroxide; Mutagenesis. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100028 Clastogenic activity of 2-chlorodeoxyadenosine in mammalian somatic cells Genet. Mol. Biol. Antonucci,Gilmara Ausech; Takahashi,Catarina Satie. The base analogue 2-chlorodeoxyadenosine (2-CdA) used for therapy in chronic resistant and advanced lymphoproliferative disorders, is cytotoxic for both dividing and non-dividing lymphocytes. The present work evaluated the clastogenic potential of this drug in vitro in human lymphocytes in culture and in vivo in BALB/c mice bone marrow cells. In human lymphocytes, the clastogenic effect of 2-CdA was studied in G1, S and G2 phases of the cell cycle, using three different concentrations (10, 20 and 40 mug/mL). The endpoints analyzed included mitotic index (MI), proliferation index (PI), sister chromatid exchange (SCE), and chromosomal aberration (CA). Statistical analysis by a variance (ANOVA) test showed a significant increase (p < 0.05) in CA... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human lymphocytes; 2-CdA; Chromosomal aberrations; SCE; Cell cycle. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000200027 Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells Genet. Mol. Biol. Antunes,Lusânia Maria Greggi; Takahashi,Catarina Satie. There is considerable interest in identifying dietary compounds which have the capacity to protect against chromosomal aberrations induced by antitumor agents. Fatty acids and their constituents are able to act as free radical scavengers. Doxorubicin (DXR) is an important chemotherapeutic agent, that also induces chromosome aberrations. Rat bone marrow cells treated simultaneously with olive oil (10 ml/kg body weight) and DXR (90 mg/kg body weight) developed significantly fewer chromosomal aberrations and abnormal metaphases than those treated with DXR alone. Tipo: Info:eu-repo/semantics/other Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47571999000200015 Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2) Genet. Mol. Biol. Rizo,Walace Fraga; Ferreira,Luis Eduardo; Colnaghi,Vanessa; Martins,Juliana Simões; Franchi,Leonardo Pereira; Takahashi,Catarina Satie; Beleboni,Rene Oliveira; Marins,Mozart; Pereira,Paulo Sérgio; Fachin,Ana Lúcia. Cancer has become a major public health problem worldwide and the number of deaths due to this disease is increasing almost exponentially. In the constant search for new treatments, natural products of plant origin have provided a variety of new compounds to be explored as antitumor agents. Tabernaemontana catharinensis is a medicinal plant that produces alkaloids with expressive antitumor activity, such as heyneanine, coronaridine and voacangine. The aim of present study was firstly to screen the cytotoxic activity of the indole alkaloids heyneanine, coronaridine and voacangine against HeLa (human cervix tumor), 3T3 (normal mouse embryo fibroblasts), Hep-2 (human laryngeal epithelial carcinoma) and B-16 (murine skin) cell lines by MTT... Tipo: Info:eu-repo/semantics/article Palavras-chave: 3T3; Apoptosis; Comet assay; Indole alkaloid; LDH. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000100015 Registros recuperados: 5 Primeira ... 1 ... Última

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