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| Tariq,Mohammad; Thomas,Shindu; Singh,Anu; Talegaonkar,Sushama. |
| Present work is aimed to develop a simple, sensitive, robust and reliable HPLC method for routine quality control of epirubicin (EPI) in bulk drug, marketed injections and polymeric nanoparticles. Separation was carried out by C18 column. Isocratic elution was carried out using mobile phase A: 0.16% o-phosphoric acid solution, B: acetonitrile and methanol mixture (80:20, v/v) in the ratio of 60:40 (A: B) while the flow rate was maintained at 1mL/min. Analyses were performed at 233.5 nm using PDA detector. Excellent linear relationship was observed between peak-area versus drug concentration in the range of 1.0-100.0 μg/mL (r2, 0.999). Developed method was found to be sensitive (Limits of detection and quantification were found to be ~8 ng/mL and ~25 ng/mL,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Epirubicin; HPLC; Polymeric nanoparticles; Quality control; Forced degradation. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400619 |
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| Mirza,Mohammad Aamir; Rahman,Mohammad Akhlaquer; Talegaonkar,Sushama; Iqbal,Zeenat. |
| A large majority of new chemical entities and many existing drug molecules exhibit poor aqueous solubility, which may limit their potential use in developing drug formulations, with optimum bioavailability. One of the approaches to improve the solubility of a poorly water soluble drug and eventually its bioavailability is complexation with agents like humic acid (HA), fulvic acid (FA), β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) and caffeine (Caff). The current work emphasized at employing these agents to prepare different complexes and their in vitro/in vivo assessment. All the complexes evaluated for their complexation efficiency and authenticated by molecular modeling; conformational analysis, differential scanning calorimetry (DSC),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Itraconazole/complexes; Itraconazole/evaluation; Itraconazole/complexes; Itraconazole/in vitro; Itraconazole/in vivo performance; Vaginal candidiasis/treatment; Drugs/solubility; Drugs/formulation. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400020 |
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