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| Cargnin,Simone Tasca; Staudt,Andressa Finkler; Menezes,Camila; Azevedo,Ana Paula de; Fialho,Saara Neri; Tasca,Tiana; Teles,Carolina Bioni Garcia; Gnoatto,Simone Baggio. |
| Trichomonas vaginalis and Leishmania spp. are protozoal species responsible for millions of cases of parasitic diseases worldwide. Considering the potential of natural products and the need for more effective and less toxic alternatives to treat trichomoniasis and leishmaniasis, this study aimed to evaluate the effect of two series of triterpenes derivatives with different modifications at C-3 and C-28 positions of the ursolic acid (UA) and betulinic acid (BA) against trophozoites of Trichomonas vaginalis and promastigotes forms of Leishmania (L.) amazonensis. The compounds modified just at C-3 were the most active. The 3β-acetyl betulinic acid (1b) reduced the trophozoites viability of T. vaginalis at 74%, followed by the 3-oxo ursolic acid and 3-oxo... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Betulinic acid; Leishmania amazonensis; Semisynthesis; Trichomonas vaginalis; Ursolic acid. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100596 |
