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Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis BJID
Cordeiro,Cynthia Azeredo; Vieira,Erica Leandro Marciano; Rocha,Natália Pessoa; Castro,Vinicius Monteiro; Oréfice,Juliana Lambert; Barichello,Tatiana; Costa,Rogerio Alves; Oréfice,Fernando; Young,Lucy; Teixeira,Antonio Lucio.
Abstract Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods: Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. Results: BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Retinochoroiditis; Toxoplasma gondii; Brain-derived neurotrophic factor.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200176
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Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C BJID
Moura,Alexandre Sampaio; Carmo,Ricardo Andrade; Teixeira,Antonio Lucio; Rocha,Manoel Otávio da Costa.
Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-α), and their soluble receptors (e.g. soluble TNF-α receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis C; Chemokines; Tumor necrosis factor receptor; Interferon-alpha; Liver fibrosis.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500013
Registros recuperados: 2
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