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	Provedor de dados BJM (1) Autor Araújo,P. V. (1) Cortés,M. E. (1) Sinisterra,R. D. (1) Teixeira,K. I. R. (1) Palavra-chave Chlorhexidine (1) Membrane-drug interactions (1) Β-cyclodextrin (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Chlorhexidine: beta-cyclodextrin inhibits yeast growth by extraction of ergosterol BJM Teixeira,K. I. R.; Araújo,P. V.; Sinisterra,R. D.; Cortés,M. E.. Chlorhexidine (Cx) augmented with beta-cyclodextrin (β-cd) inclusion compounds, termed Cx:β-cd complexes, have been developed for use as antiseptic agents. The aim of this study was to examine the interactions of Cx:β-cd complexes, prepared at different molecular ratios, with sterol and yeast membranes. The Minimal Inhibitory Concentration (MIC) against the yeast Candida albicans (C.a.) was determined for each complex; the MICs were found to range from 0.5 to 2 µg/mL. To confirm the MIC data, quantitative analysis of viable cells was performed using trypan blue staining. Mechanistic characterization of the interactions that the Cx:β-cd complexes have with the yeast membrane and assessment of membrane morphology following exposure to Cx:β-cd complexes were... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chlorhexidine; Β-cyclodextrin; Membrane-drug interactions. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000200047 Registros recuperados: 1 Primeira ... 1 ... Última

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