|
|
| Almeida,Tamires Cunha; Seibert,Janaina Brandão; Almeida,Sávio Henrique de Souza; Amparo,Tatiane Roquete; Teixeira,Luiz Fernando de Medeiros; Barichello,Jose Mario; Postacchini,Bruna Bueno; Santos,Orlando David Henrique dos; Silva,Glenda Nicioli da. |
| Antimicrobial and antitumor activities of resveratrol, a compound found mainly in grapes, have already been demonstrated. However, its low bioavailability is a limiting factor for therapeutic application. Polymeric micelles can be an approach to solve this problem since they can encapsulate hydrophobic substances. We developed and characterized micellar formulations containing resveratrol and evaluated their cytotoxic and antimicrobial effects. The formulations were prepared by the cold dispersion method with different concentrations of F127 (5 or 10% w/w) and resveratrol (500 or 5000 µM). The formulations were characterized according to size, polydispersity index, pH, encapsulation rate and in vitro release. Cytotoxic effect was evaluated on a bladder... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimicrobial activity; Cytotoxic activity; F127®; Polymeric micelles; Resveratrol. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100567 |
| |
