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| Shi,Luye; Jiang,Mengwan; Li,Mengyang; Shang,Xiaozhen; Li,Xiujuan; Huang,Maolin; Wu,Yue; Qiao,Congcong; Wang,Xinrui; Tian,Xiangyu; Shi,Yuhua; Wang,Zhenlong. |
| ABSTRACT The response mechanism and interaction patterns of HIF-1α and p53 in animals in an hypoxic environment are crucial for their hypoxic tolerance and adaptation. Many studies have shown that underground rodents have better hypoxic adaptation characteristics. However, the mechanism by which HIF-1α and p53 in underground rodents respond to hypoxic environments compared with in ground rodents remains unclear. Further, whether a synergy between HIF-1α and p53 enables animals tolerate extremely hypoxic environments is unclear. We studied HIF-1α and p53 expression in the brain tissue and cell apoptosis in the hippocampal CA1 region during 6 hours of acute hypoxia (5% oxygen) in Lasiopodomys mandarinus (Milne-Edwards, 1871) and Lasiopodomys brandtii (Radde,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Comparative biology; Hippocampal CA1 region; Oxygen; Subterranean rodents. |
| Ano: 2021 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-46702021000100305 |
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