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	Provedor de dados BJMBR (2) Autor Bousquet,P. (2) Tibiriçá,E. (2) Araújo,C.V. (1) Catelli,M. (1) Estato,V. (1) Feldman,J. (1) Mais... Palavra-chave Antiarrhythmic agents (1) Antihypertensive agents (1) Arterial hypertension (1) Autonomic nervous system (1) Baclofen (1) Clonidine (1) Ischemia (1) LNP 509 (1) Mesenteric microcirculation (1) Rilmenidine (1) Sudden death (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2004 (1) 2003 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Protective effects of centrally acting sympathomodulatory drugs on myocardial ischemia induced by sympathetic overactivity in rabbits BJMBR Catelli,M.; Feldman,J.; Bousquet,P.; Tibiriçá,E.. It is recognized that an imbalance of the autonomic nervous system is involved in the genesis of ventricular arrhythmia and sudden death during myocardial ischemia. In the present study we investigated the effects of clonidine and rilmenidine, two centrally acting sympathomodulatory drugs, on an experimental model of centrally induced sympathetic hyperactivity in pentobarbital-anesthetized New Zealand albino rabbits of either sex (2-3 kg, N = 89). We also compared the effects of clonidine and rilmenidine with those of propranolol, a ß-blocker, known to induce protective cardiovascular effects in patients with ischemic heart disease. Central sympathetic stimulation was achieved by intracerebroventricular injection of the excitatory amino acid L-glutamate... Tipo: Info:eu-repo/semantics/article Palavras-chave: Autonomic nervous system; Antihypertensive agents; Antiarrhythmic agents; Ischemia; Sudden death. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100012 Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats BJMBR Estato,V.; Araújo,C.V.; Bousquet,P.; Tibiriçá,E.. We investigated the acute effects of centrally acting antihypertensive drugs on the microcirculation of pentobarbital-anesthetized spontaneously hypertensive rats (SHR). The effects of the sympatho-inhibitory agents clonidine and rilmenidine, known to activate both alpha2-adrenoceptors and nonadrenergic I1-imidazoline binding sites (I1BS) in the central nervous system, were compared to those of dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H -pyrrol-2-yl)-amine hydrochloride (LNP 509), which selectively binds to the I1BS. Terminal mesenteric arterioles were observed by intravital microscopy. Activation of the central sympathetic system with L-glutamate (125 µg, ic) induced marked vasoconstriction of the mesenteric microcirculation (27 ± 3%; N = 6, P <... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesenteric microcirculation; Arterial hypertension; Clonidine; Rilmenidine; Baclofen; LNP 509. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000014 Registros recuperados: 2 Primeira ... 1 ... Última

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