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	Provedor de dados BJPS (1) Autor Carneiro,Guilherme (1) Ferreira,Lucas Antônio Miranda (1) Leite,Elaine Amaral (1) Silva,Flávia Lidiane Oliveira da (1) Tinoco,Letícia Márcia da Silva (1) Palavra-chave All-trans-retinoic acid (1) Breast neoplasms.Drug delivery (1) Hyaluronic acid (1) Nanoemulsion (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Hyaluronic acid-coated nanoemulsions loaded with a hydrophobic ion pair of all-trans retinoic acid for improving the anticancer activity BJPS Tinoco,Letícia Márcia da Silva; Silva,Flávia Lidiane Oliveira da; Ferreira,Lucas Antônio Miranda; Leite,Elaine Amaral; Carneiro,Guilherme. All-trans retinoic acid (ATRA) has been studied for the treatment of cancer, including leukemia and breast cancer. This work aims to develop nanoemulsions (NE) loaded with a hydrophobic ion pair (HIP) of all-trans retinoic acid (ATRA) and a lipophilic amine, stearylamine (SA), and coated with hyaluronic acid (HA) to enhance anticancer activity and reducing toxicity. Blank NE was prepared by spontaneous emulsification and optimized prior to HIP incorporation. NE-ATRA was electrostatically coated with different concentrations of HA. Incorporation of ATRA-SA led to monodisperse NE with small size (129 ± 2 nm; IP 0.18 ± 0.005) and positive zeta potential (35.7 ± 1.0 mV). After coating with 0.5 mg/mL HA solution, the mean diameter slightly increased to 158 ± 5... Tipo: Info:eu-repo/semantics/article Palavras-chave: All-trans-retinoic acid; Breast neoplasms.Drug delivery; Hyaluronic acid; Nanoemulsion. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400616 Registros recuperados: 1 Primeira ... 1 ... Última

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