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	Provedor de dados Nature Precedings (1) Autor Antony Williams (1) Jean-Claude Bradley (1) Kevin Owens (1) Khalid Mirza (1) Tom Osborne (1) Palavra-chave Chemistry (1) Pharmacology (1) Tipo do documento Manuscript (1) Ano 2008 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Optimization of the Ugi reaction using parallel synthesis and automated liquid handling Nature Precedings Jean-Claude Bradley; Khalid Mirza; Kevin Owens; Tom Osborne; Antony Williams. The Ugi reaction has proved to be a convenient way to quickly create diverse libraries of compounds. It involves the reaction of an amine, an aldehyde, a carboxylic acid and an isonitrile typically in methanol at room temperature. The Ugi reaction has often been used as a tool in the synthesis of pharmacologically active molecules. It has been observed that Ugi products sometimes precipitate in pure form from the reaction mixture. This is a very fortunate outcome since the reaction can then be easily scaled up without requiring costly purification procedures such as chromatography. It would be most beneficial to optimize the Ugi product yield as obtained directly from filtering the reaction mixture without further treatment. To this end we utilized a... Tipo: Manuscript Palavras-chave: Chemistry; Pharmacology. Ano: 2008 URL: http://precedings.nature.com/documents/2237/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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