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Effect of sodium carboxymethylcellulose and methylprednisolone on the healing of jejunal anastomoses in rats BJMBR
Sousa,A.A.; Petroianu,A.; Trapiello Neto,V.; Rios,V.S.; Barbosa,A.J.A..
Sodium carboxymethylcellulose (SCMC) has been effective in reducing adhesion formation and corticosteroids reduce the inflammatory process. The objective of this study was to define the intraperitoneal (ip) effects of SCMC combined with intramuscular (im) methylprednisolone on peritoneal adhesion formation and on jejunal anastomosis healing in rats. Twenty Wistar rats (200-350 g) were divided into four groups (N = 5): groups I and III (controls) 5 and 21 days of treatment before sacrifice, respectively; groups II and IV (experimental groups) 5 and 21 days of treatment, respectively. SCMC (1%) was infused into the abdominal cavity and methylprednisolone (10 mg kg-1 day-1) was injected im daily from the day before surgery for animals of groups II and IV. All...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bowel anastomosis; Peritoneal adhesions; Sodium carboxymethylcellulose; Corticosteroid; Histology; Wound healing.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400012
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