|
|
|
|
| |
|
|
Hsieh,Yao-Yuan; Chang,Chi-Chen; Tsai,Fuu-Jen; Peng,Ching-Tien; Yeh,Lian-Shun; Lin,Cheng-Chieh. |
Insulin-like growth factor II (IGF2) has been shown to play a role in abnormal cell growth and carcinogenesis. We investigated if the IGF2 gene Apa I polymorphism at exon 9 was associated with the susceptibility to endometriosis, analyzing 120 women with moderate/severe endometriosis and 103 controls. The genotype frequencies did not differ statistically between the endometriosis (aa = 25.4, ab = 57.4, bb = 17.2%) and control (aa = 20.8 ab = 52.8, bb = 26.4%) groups. The allele frequencies did not differ either: a = 54.1, b = 45.9% among women with endometriosis and a = 47.2, b = 52.8% in the control group. Therefore, no indication was found for an association of this polymorphism with endometriosis susceptibility. |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Endometriosis; Insulin-like growth factor; IGF-2. |
Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000200006 |
| |
|
|
Lin,Wei-De; Lin,Shuan-Pei; Wang,Chung-Hsing; Tsai,Yushin; Chen,Chih-Ping; Tsai,Fuu-Jen. |
Cleidocranial dysplasia (CCD) is an autosomal dominant human skeletal disorder comprising hypoplastic clavicles, wide cranial sutures, supernumerary teeth, short stature, and other skeletal abnormalities. It is known that mutations in the human RUNX2 gene mapped at 6p21 are responsible for CCD. We analyzed the mutation patterns of the RUNX2 gene by direct sequencing in six Taiwanese index cases with typical CCD. One of the patients was a familial case and the others were sporadic cases. Sequencing identified four mutations. Three were caused by single nucleotide substitutions, which created a nonsense (p.R391X), two were missense mutations (p.R190W, p.R225Q), and the forth was a novel mutation (c.1119delC), a one-base deletion. Real time quantitative PCR... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cleidocranial dysplasia; CCD; RUNX2; RUNX2 deletion mutation. |
Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200005 |
| |
|
|
|