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	Provedor de dados BJMBR (2) Autor Mota,I. (2) Umekita,L.F. (2) Ramos,D.P. (1) Palavra-chave Clearance (2) Trypanosoma cruzi (2) Acute phase (1) Chronic mouse antibodies (1) Complement-mediated lysis (1) Cytokines (1) Protection (1) Susceptible mice (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2000 (1) 1997 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última How are antibodies involved in the protective mechanism of susceptible mice infected with T. cruzi? BJMBR Umekita,L.F.; Mota,I.. Host resistance to Trypanosoma cruzi is dependent on both natural and acquired immune responses. During the acute phase of the infection the presence of IFN-<FONT FACE=Symbol>g</font>, TNF-<FONT FACE=Symbol>a</font>, IL-12 and GM-CSF has been closely associated with resistance, whereas TGF-ß and IL-10 have been associated with susceptibility. Several investigators have demonstrated that antibodies are responsible for the survival of susceptible animals in the initial phase of infection and for the maintenance of low levels of parasitemia in the chronic phase. However, how this occurs is not yet understood. Our results and other data in the literature support the hypothesis that the protective role of antibodies in the acute phase of... Tipo: Info:eu-repo/semantics/other Palavras-chave: Trypanosoma cruzi; Chronic mouse antibodies; Clearance; Cytokines; Acute phase; Susceptible mice. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000300001 Clearance-inducing antibodies are responsible for protection against the acute phase of Trypanosoma cruzi infection in mice BJMBR Umekita,L.F.; Ramos,D.P.; Mota,I.. A study was conducted on mice infected with strains Y and CL of Trypanosoma cruzi. The ability of anti-Y and anti-CL sera to induce complement-mediated lysis, immune clearance and protection against the acute phase of the infection was studied using homologous anti-Y or anti-CL serum tested with the Y or CL strain, or heterologous anti-Y serum tested with the CL strain or anti-CL serum tested with the Y strain. Complement-mediated lysis was induced by both homologous and heterologous antisera but protection was afforded only by homologous antisera. Immune clearance was induced by homologous but not by heterologous antisera. Antisera with high clearance ability were able to confer protection whereas antisera with high lytic ability were not. These results... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Clearance; Complement-mediated lysis; Protection. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000009 Registros recuperados: 2 Primeira ... 1 ... Última

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