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Glucocorticoid susceptibility and in vivo ABCB1 activity differ in murine B cell subsets Anais da ABC (AABC)
COSTA,KELLI M. DA; VALENTE,RAPHAEL C.; SILVA,JOYLE M.C. DA; PAIVA,LUCIANA S. DE; RUMJANEK,VIVIAN M..
Abstract Glucocorticoids are produced and released by the adrenal gland and become elevated in response to stress. Although glucocorticoids are well known for their immunosuppressive effects, less is known about their effects on B cells. ABCB1 is an efflux pump expressed in both cancer and normal cells, modulating the gradient of various metabolites, including hydrocortisone. Our goal was to evaluate the effect of this glucocorticoid on murine B cell differentiation and whether sensitivity to hydrocortisone could be related to ABCB1 activity in vivo. C57BL/6 mice received one or three consecutive i.p. injections of hydrocortisone (70, 140 and 200 mg/kg/day). ABCB1 activity was evaluated via the rhodamine-123 transport and inhibited by cyclosporin A in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: ABC transporters; B cells; Immunoregulation; Steroid.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000603081
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