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| Alves,Endrigo Gabellini Leonel; Serakides,Rogéria; Rosado,Isabel Rodrigues; Paez,Omar Leonardo Aristizabal; Varon,Jéssica Alejandra Castro; Machado,Felipe Nemer; Fukushima,Fabíola Bono; Góes,Alfredo Miranda; Rezende,Cleuza Maria de Faria. |
| ABSTRACT: The aim of this study was to evaluate the effect of osteoprogenitor cells derived from mesenchymal stem cells from adipose tissue (OC-AD-MSCs), and differentiated into osteoblasts, in the treatment of critical bone defects in dogs. Adipose tissue derived mesenchymal stem cells (AD-MSCs) were subjected to osteogenic differentiation for 21 days and used in the treatment of bone defects in dogs radius. Either three experimental groups were bone defects treated with OC-AD-MSCs (OC), defects filled with autogenous bone (Control- C +), or empty defects (Control- C -). Bone regeneration was assessed by radiology, densitometry, and histomorphometry. The area of new bone formation was higher in the OC group compared to the control group (C-) on... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bone regeneration; Orthopedics; Cellular therapy; Fracture non-union. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000700604 |
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