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Diabetic Peripheral Neuropathies: A Morphometric Overview International Journal of Morphology
Fazan,Valéria Paula Sassoli; Vasconcelos,Carlos Augusto Carvalho de; Valença,Marcelo Moraes; Nessler,Randy; Moore,Kenneth Charles.
Diabetes is now considered one of the main threats to human health in the 21st century and many researchers are dedicated to investigate the physiopathology of the disease, with further insights on the managements of its major complications. Since understanding the pathophysiology of the major complications of diabetes and their underlying processes is mandatory, experimental models of the disease may be useful as they allow the recognition of the early mechanisms involved in the long-term complications of diabetes. Peripheral nerve involvement is highly frequent in diabetes mellitus and it has been documented that one third of diabetic patients have peripheral neuropathy. The true prevalence is not known and reports vary from 10% to 90% in diabetic...
Tipo: Journal article Palavras-chave: Diabetes; Experimental models; Neuropathy; Morphometry.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100007
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Transmission Electron Microscopy Studies of the Vestibulocochlear Nerve in Chronic Diabetic Rats International Journal of Morphology
Vasconcelos,Carlos Augusto Carvalho de; Fazan,Valéria Paula Sassoli; Moore,Kenneth Charles; Nessler,Randy Alan; Valença,Marcelo Moraes.
It is widely described in the literature that diabetic patients present hearing impairment. Despite the histological alterations of the internal ear structures in these patients as well as in experimental models of diabetes, to the best of our knowledge, an histological evaluation of the vestibulocochlear nerve have not been performed. In the present study, ultrastructural alterations are described and compared between a spinal nerves and a cranial nerve in rats with chronic induced diabetes. Male Wistar rats (n = 12), fed with standard diet from the animal care facility at 42 days of age were used. Induced diabetic animals (n=6) were fasted for 12 hours prior to being injected intraperitoneally with streptozotocin (STZ - 60mg/kg) in a single dose. Control...
Tipo: Journal article Palavras-chave: Experimental diabetes; Vestibulocochlear nerve; Ultrastructure; Myelinated fibers; Axonal atrophy.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000100045
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