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	Provedor de dados BJMBR (2) Autor Vassilieff,V.S. (2) Boni-Mitake,M. (1) Cordellini,S. (1) Costa,H. (1) Malvezzi,C.K. (1) Moreira,E.G. (1) Rogero,J.R. (1) Spencer,P.J. (1) Vassilieff,I. (1) Mais... Palavra-chave Blood pressure (1) Chromatography (1) Circular dichroism (1) Crotamine (1) DMSA (1) Gamma radiation (1) L-arginine (1) Plumbism (1) Rat (1) Tissue lead mobilization (1) Toxicity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Info:eu-repo/semantics/other (1) Ano 2001 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effects of 60Co gamma radiation on crotamine BJMBR Boni-Mitake,M.; Costa,H.; Spencer,P.J.; Vassilieff,V.S.; Rogero,J.R.. Ionizing radiation can change the molecular structure and affect the biological properties of biomolecules. This has been employed to attenuate animal toxins. Crotamine is a strongly basic polypeptide (pI 10.3) from Crotalus durissus terrificus venom composed of 42 amino acid residues. It induces skeletal muscle spasms leading to a spastic paralysis of hind limbs in mice. The objective of the present study was to carry out a biochemical study and a toxic activity assay on native and irradiated crotamine. Crotamine was purified from C.d. terrificus venom by Sephadex G-100 gel filtration followed by ion-exchange chromatography, and irradiated at 2 mg/ml in 0.15 M NaCl with 2.0 kGy gamma radiation emitted by a 60Co source. The native and irradiated toxins... Tipo: Info:eu-repo/semantics/article Palavras-chave: Crotamine; Gamma radiation; Chromatography; Toxicity; Circular dichroism. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001200004 Effect of L-arginine, dimercaptosuccinic acid (DMSA) and the association of L-arginine and DMSA on tissue lead mobilization and blood pressure level in plumbism BJMBR Malvezzi,C.K.; Moreira,E.G.; Vassilieff,I.; Vassilieff,V.S.; Cordellini,S.. Lead (Pb)-induced hypertension is characterized by an increase in reactive oxygen species (ROS) and a decrease in nitric oxide (NO). In the present study we evaluated the effect of L-arginine (NO precursor), dimercaptosuccinic acid (DMSA, a chelating agent and ROS scavenger), and the association of L-arginine/DMSA on tissue Pb mobilization and blood pressure levels in plumbism. Tissue Pb levels and blood pressure evolution were evaluated in rats exposed to: 1) Pb (750 ppm, in drinking water, for 70 days), 2) Pb plus water for 30 more days, 3) Pb plus DMSA (50 mg kg-1 day-1, po), L-arginine (0.6%, in drinking water), and the combination of L-arginine/DMSA for 30 more days, and 4) their respective matching controls. Pb exposure increased Pb levels in the... Tipo: Info:eu-repo/semantics/other Palavras-chave: L-arginine; DMSA; Tissue lead mobilization; Plumbism; Blood pressure; Rat. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000016 Registros recuperados: 2 Primeira ... 1 ... Última

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