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| Silva,Deborah Galvão Coelho da; Kanazawa,Luiz Kae Sales; Vecchia,Débora Dalla. |
| Schizophrenia, in general, is characterized by severe and disabling mental alterations, characterized by the impairment of one’s mental, behavioral and social activities, developing certain clinical symptoms, relevant to the diagnosis. The drugs used for the reversion of the symptoms cause several adverse effects that affect the patient’s health and well-being, such as motor, endocrine and cardiovascular damages. For a long time, little was known about the origin and the treatment of schizophrenia, which has become a curiosity for science, originating countless researches and theories that are background for several treatments. It is known that alterations in dopaminergic pathways are related to the development of the symptoms of the disease, and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Schizophrenia; Pharmacotherapy; Antipsychotics; Aripiprazole; Metabolic Syndrome. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100552 |
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| Vecchia,Débora Dalla; Schamne,Marissa Giovanna; Ferro,Marcelo Machado; Santos,Ana Flávia Chaves dos; Latyki,Camila Lupepsa; Lara,Danilo Vieira de; Ben,Juliana; Moreira,Eduardo Luiz; Prediger,Rui Daniel; Miyoshi,Edmar. |
| Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the slow and progressive death of dopaminergic neurons in the (substantia nigra pars compact). Hypericum perforatum (H. perforatum) is a plant widely used as an antidepressant, that also presents antioxidant and anti-inflammatory properties. We evaluated the effects of H. perforatum on the turning behavior of rats submitted to a unilateral administration of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle as an animal model of PD. The animals were treated with H. perforatum (100, 200, or 400 mg/kg, v.o.) for 35 consecutive days (from the 28th day before surgery to the 7th day after). The turning behavior was evaluated at 7, 14 and 21 days after the surgery,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson's disease/treatment/experimental study; H. perforatum/phytotherapy/neuroprotective effect; Turning behavior; 6-OHDA. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100111 |
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