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	Provedor de dados BJID (2) Autor Velasque,Luciane S. (2) Cardoso,Sandra Wagner (1) Estrela,Rita de Cássia E. (1) Fleury,Marcos K. (1) Gonçalves,José Carlos Saraiva (1) Grinsztejn,Beatriz (1) Kritski,Afrânio L. (1) Oliveira,Martha M. (1) Santos,Eliana Abreu (1) Silva,José Roberto Lapa e (1) Torres,Thiago Silva (1) Veloso,Valdilea G. (1) Mais... Palavra-chave Adverse event (1) Aging (1) Antiretroviral (1) HIV (1) Hepatotoxicity (1) Induced liver injury from treatment of tuberculosis (1) Polymorphisms of CYP2E1 and GST (1) Pulmonary tuberculosis (1) Toxicity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2014 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST BJID Santos,Eliana Abreu; Gonçalves,José Carlos Saraiva; Fleury,Marcos K.; Kritski,Afrânio L.; Oliveira,Martha M.; Velasque,Luciane S.; Silva,José Roberto Lapa e; Estrela,Rita de Cássia E.. ABSTRACT Setting: Treatment of tuberculosis (TB) can result in Drug-Induced Liver Injury (DILI) since hepatotoxic metabolites are formed during the biotransformation of isoniazid (INH).DILI can be related to the genetic profile of the patient. Single nucleotide polymorphisms in the CYP2E1 gene and GSTM1 and GSTT1 deletion polymorphisms have been associated with adverse events caused by INH. Objective: To characterize the genetic polymorphisms of CYP2E1, GSTT1 and GSTM1 in TB carriers. Design: This is an observational prospective cohort study of 45 patients undergoing treatment of TB. PCR-RFLP and multiplex-PCR were used. Results: The distribution of genotypic frequency in the promoter region (CYP2E1 gene) was: 98% wild genotype and 2% heterozygous.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adverse event; Polymorphisms of CYP2E1 and GST; Induced liver injury from treatment of tuberculosis; Hepatotoxicity; Pulmonary tuberculosis. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600381 Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age BJID Torres,Thiago Silva; Cardoso,Sandra Wagner; Velasque,Luciane S.; Veloso,Valdilea G.; Grinsztejn,Beatriz. Toxicity is the most frequently reported reason for modifying or discontinuing the first combined antiretroviral therapy regimens, and it can cause significant morbidity, poor quality of life and also can be an important barrier to adherence, ultimately resulting in treatment failure and viral resistance. Elderly patients with HIV/AIDS (≥50 years) may have a different profile in terms of treatment modification due to higher incidence of comorbidities and polypharmacy. The aim of this study was to describe the incidence of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity (TOX-MOD) during the first year of treatment at the IPEC – FIOCRUZ HIV/AIDS cohort, Rio de Janeiro, Brazil, stratified by age. Demographic, clinical... Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Toxicity; Aging; Antiretroviral. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100034 Registros recuperados: 2 Primeira ... 1 ... Última

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