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| Pereira,NB; Kalapothakis,E; Vasconcelos,AC; Chatzaki,M; Campos,LP; Vieira,FO; Verçosa,BLA; Silva,SS; Ferreira,WM; Moro,L. |
| Envenomation by Loxosceles bites is characterized by dermonecrotic and/or systemic features that lead to several clinical signs and symptoms called loxoscelism. Dermonecrotic lesions are preceded by thrombosis of the dermal plexus. Recent studies show that atheromatous plaque is prone to thrombosis due to endothelial cell apoptosis. To the best of our knowledge, there are no reports of microscopic dermal lesion and endothelial cell apoptosis induced by Loxosceles similis venom in the literature. Thus, the aim of the present study is to describe histological lesions induced by L. similis venom in rabbit skin and to elucidate whether apoptosis of endothelial cells is involved in the pathogenesis of loxoscelism. Forty male rabbits were split into two groups:... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Loxosceles similis; Loxoscelism; Dermonecrosis; Cutaneous loxoscelism; Apoptosis. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000300005 |
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