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| Silva,Aline Teixeira Maciel e; Magalhães,Cássia Gonçalves; Duarte,Lucienir Pains; Mussel,Wagner da Nova; Ruiz,Ana Lucia Tasca Gois; Shiozawa,Larissa; Carvalho,João Ernesto de; Trindade,Izabel Cristina; Vieira Filho,Sidney Augusto. |
| ABSTRACT The triterpene lupeol (1) and some of its esters are secondary metabolites produced by species of Celastraceae family, which have being associated with cytotoxic activity. We report herein the isolation of 1, the semi-synthesis of eight lupeol esters and the evaluation of their in vitro activity against nine strains of cancer cells. The reaction of carboxylic acids with 1 and DIC/DMAP was used to obtain lupeol stearate (2), lupeol palmitate (3) lupeol miristate (4), and the new esters lupeol laurate (5), lupeol caprate (6), lupeol caprilate (7), lupeol caproate (8) and lupeol 3’,4’-dimethoxybenzoate (9), with high yields. Compounds 1-9 were identified using FT-IR, 1H, 13C-NMR, CHN analysis and XRD data and were tested in vitro for proliferation of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lupeol/in vitro evaluation; Lupeol ester; K-562 cells; XRD method; Antiproliferative effect.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300621 |
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| Amparo,Tatiane Roquete; Rodrigues,Ivanildes Vasconcelos; Seibert,Janaína Brandão; Almeida,Tamires Cunha; Cabral,Vivette Appolinário Rodrigues; Vieira,Paula Melo de Abreu; Brandão,Geraldo Célio; Oliveira,Mauro Lúcio Gonçalves de; Silva,Glenda Nicioli da; Santos,Orlando David Henrique dos; Vieira Filho,Sidney Augusto; Teixeira,Luiz Fernando Medeiros; Souza,Gustavo Henrique Bianco de. |
| Due to the increase of bacterial resistance, the search for new antibiotics is necessary and the medicinal plants represent its most important source. The aim of this study was to evaluate the antibacterial property of extract and fractions from Protium spruceanum leaves, against pathogenic bacteria. By means of diffusion and microdilution assays, the crude extract was active against the nine bacteria tested being the hydromethanolic fraction the most active. During phytochemical procedures, procyanidin (1) and catechin (2) were identified as the main antibacterial constituents of this fraction. In silico results obtained using PASSonline tool indicated 1 and 2 as having good potential to interact with different targets of currently used antibiotics. These... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Protium spruceanum; Burseraceae; Procyanidin; Catechin; Antibacterial activity. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100623 |
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