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	Provedor de dados Nature Precedings (1) Autor Amineni Umamaheswari (1) Dibyabhaba Pradhan (1) Vijayasree Potluri (1) Palavra-chave Bioinformatics (1) Cancer (1) Tipo do documento Poster (1) Ano 2010 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Ligand Based Virtual Screening to Design Novel Human MEK1 Protein Inhibitors for Potential Development of Drugs Against Melanoma Nature Precedings Vijayasree Potluri; Dibyabhaba Pradhan; Amineni Umamaheswari. The Ras-dependent Raf/MEK/ERK signaling pathway is a major regulator of cell proliferation and survival. Hyper activation of the pathway is frequently observed in human malignancies as a result of aberrant activation of receptor tyrosine kinases or mutations in RAF (V600E). MEK1 is dual-specificity tyrosine/threonine protein kinases found in the pathway. The RAF mutation (present in 50% of melanomas) have been shown to be highly dependent on MEK1 activity and also MEK1 is the only acknowledged activator of ERK, making them attractive targets for therapeutic intervention. In view of its importance, identification of potent inhibitor against MEK1 may be valuable to design effective drugs against melanoma. Inhibitors for human MEK1 reported till dates have... Tipo: Poster Palavras-chave: Cancer; Bioinformatics. Ano: 2010 URL: http://precedings.nature.com/documents/4901/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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