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| Arantes,Paula de Oliveira; Santos,Quesia Nery dos; Freitas,Zaida Maria Faria de; Pyrrho,Alexandre dos Santos; Cerqueira-Coutinho,Cristal; Villa,Ana Lucia Vazquez; Santos,Elisabete Pereira dos; Ricci-Júnior,Eduardo. |
| ABSTRACT This article reports the development and characterization of a nanoemulsion (NE) able to improve the cutaneous penetration of nifedipine. NE with nifedipine was development and characterized, presenting droplet size of 20 nm with low polydispersity index (IP<0.1), spherical shape without aggregation, pH compatible with typical skin levels and stability evaluated by seven months. In the permeation studies, a classical formulation based in an oil/water cream containing nifedipine was used for comparison with NE. Nanoemulsion promoted and improved the retention of nifedipine in the epidermis and dermis in relation to classical formulation. This promoting effect is related to the nanometric size of the droplets of the NE (20 nm), which give him a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Topical nifedipine/cutaneous permeation; Nanoemulsion/characterization; Stability; Cutaneous permeation/study; Healing of wounds. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200628 |
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