Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (2) Autor Castillo-Henkel,E.F. (2) Lozano-Cuenca,J. (2) López-Canales,J.S. (2) López-Canales,O.A. (2) Villagrana-Zesati,J.R. (2) Aguilar-Carrasco,J.C. (1) González-Hernández,A. (1) López-Mayorga,R.M. (1) Morín-Zaragoza,R. (1) Rodríguez-Choreão,J.D. (1) Mais... Palavra-chave K+ channels (2) Rat aorta (2) Vasorelaxation (2) Clobenzorex (1) NO-cGMP (1) NO-cGMP/PKG pathway (1) PKG pathway (1) Triiodothyronine (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2016 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Pharmacological study of the mechanisms involved in the vasodilator effect produced by the acute application of triiodothyronine to rat aortic rings BJMBR Lozano-Cuenca,J.; López-Canales,O.A.; Aguilar-Carrasco,J.C.; Villagrana-Zesati,J.R.; López-Mayorga,R.M.; Castillo-Henkel,E.F.; López-Canales,J.S.. A relationship between thyroid hormones and the cardiovascular system has been well established in the literature. The present in vitro study aimed to investigate the mechanisms involved in the vasodilator effect produced by the acute application of 10-8–10-4 M triiodothyronine (T3) to isolated rat aortic rings. Thoracic aortic rings from 80 adult male Wistar rats were isolated and mounted in tissue chambers filled with Krebs-Henseleit bicarbonate buffer in order to analyze the influence of endothelial tissue, inhibitors and blockers on the vascular effect produced by T3. T3 induced a vasorelaxant response in phenylephrine-precontracted rat aortic rings at higher concentrations (10-4.5–10-4.0 M). This outcome was unaffected by 3.1×10-7 M glibenclamide,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Triiodothyronine; Rat aorta; Vasorelaxation; NO-cGMP/PKG pathway; K+ channels. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000800604 Possible mechanisms involved in the vasorelaxant effect produced by clobenzorex in aortic segments of rats BJMBR Lozano-Cuenca,J.; González-Hernández,A.; López-Canales,O.A.; Villagrana-Zesati,J.R.; Rodríguez-Choreão,J.D.; Morín-Zaragoza,R.; Castillo-Henkel,E.F.; López-Canales,J.S.. Clobenzorex is a metabolic precursor of amphetamine indicated for the treatment of obesity. Amphetamines have been involved with cardiovascular side effects such as hypertension and pulmonary arterial hypertension. The aim of the present study was to investigate whether the direct application of 10–9–10–5 M clobenzorex on isolated phenylephrine-precontracted rat aortic rings produces vascular effects, and if so, what mechanisms may be involved. Clobenzorex produced an immediate concentration-dependent vasorelaxant effect at the higher concentrations (10–7.5–10–5 M). The present outcome was not modified by 10–6 M atropine (an antagonist of muscarinic acetylcholine receptors), 3.1×10–7 M glibenclamide (an ATP-sensitive K+ channel blocker), 10–3 M... Tipo: Info:eu-repo/semantics/article Palavras-chave: Clobenzorex; Rat aorta; Vasorelaxation; NO-cGMP; PKG pathway; K+ channels. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900605 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco