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| Resende,Marianne G.; Fux,Blima; Caetano,Brália C.; Mendes,Erica A.; Silva,Neide M.; Ferreira,Adriana M.; Melo,Maria Norma; Vitor,Ricardo W.A.; Gazzinelli,Ricardo T.. |
| Toxoplasma gondii strains displaying the Type I/III genotype are associated with acquired ocular toxoplasmosis in humans. Here, we used a mice model to characterize some immunological mechanisms involved in host resistance to infection with such strains. We have chosen the Type I/III strains D8, G2 and P-Br, which cause a chronic infection in mice that resembles human toxoplamosis. Mice deficient of molecules MyD88, IFN-gamma, and IL-12 were susceptible to all three parasite strains. This finding indicates the importance of innate mechanisms in controlling infection. On the other hand, MHC haplotype did not influenced resistance/susceptibility; since mice lineages displaying a same genetic background but different MHC haplotypes (H2b or H2d) developed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Toxoplasma gondii strains; Innate immunity; Acquired immunity; TLR and MHC. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652008000100005 |
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