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	Provedor de dados Genet. Mol. Biol. (1) Autor Grubisa,Ivana (1) Jozic,Tanja (1) Krstic,Slobodan (1) Milasin,Jelena (1) Milicic,Biljana (1) Otasevic,Petar (1) Vucinic,Nada (1) Mais... Palavra-chave Atherosclerosis (1) Gene polymorphisms (1) Glutathione S-transferases (1) Oxidative stress (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2018 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population Genet. Mol. Biol. Grubisa,Ivana; Otasevic,Petar; Vucinic,Nada; Milicic,Biljana; Jozic,Tanja; Krstic,Slobodan; Milasin,Jelena. Abstract Oxidative stress (OS) plays an important role in atherogenesis and since glutathione S-transferases (GSTs) provide protection against OS, we have tested the hypothesis that deletion polymorphisms in two GSTs (GSTM1 and GSTT1) may affect the risk of developing atherosclerosis. A total of 382 individuals (200 patients with atherosclerosis and 182 healthy controls) were included in this association study. Genomic DNA was isolated from peripheral blood cells or from buccal epithelial cells and genotyping was performed using multiplex-PCR or real-time PCR methods. GSTM1 null genotype was significantly more frequent in atherosclerotic patients than in controls (52.0% vs 34.1%) and individuals with the GSTM1 null genotype had an approximately 2-fold... Tipo: Info:eu-repo/semantics/article Palavras-chave: Atherosclerosis; Gene polymorphisms; Glutathione S-transferases; Oxidative stress. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000100035 Registros recuperados: 1 Primeira ... 1 ... Última

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