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	Provedor de dados Biol. Res. (1) Autor TANNA,BHAVNA (1) WILLIAMS,ALAN J (1) Palavra-chave Ca2+-release channel (1) Calcium (1) Ryanodine (1) Sarcoplasmic reticulum (1) Single channel (1) Tipo do documento Journal article (1) Ano 2004 (1) País Chile (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última The interaction of ryanoids with individual ryanodine receptor channels Biol. Res. WILLIAMS,ALAN J; TANNA,BHAVNA. Ryanodine binds with high affinity and specificity to a class of Ca2+-release channels known as ryanodine receptors (RyR). The interaction with RyR results in a dramatic alteration in function with open probability (Po) increasing markedly and rates of ion translocation modified. We have investigated the features of ryanodine that govern the interaction of the ligand with RyR and the mechanisms underlying the subsequent alterations in function by monitoring the effects of congeners and derivatives of ryanodine (ryanoids) on individual RyR2 channels. While the interaction of all tested ryanoids results in an increased Po, the amplitude of the modified conductance state depends upon the structure of the ryanoid. We propose that different rates of cation... Tipo: Journal article Palavras-chave: Calcium; Ca2+-release channel; Sarcoplasmic reticulum; Ryanodine; Single channel. Ano: 2004 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400006 Registros recuperados: 1 Primeira ... 1 ... Última

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