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| Peter,C.M.; Waller,S.B.; Picoli,T.; Osório,L.G.; Zani,J.L.; Meireles,M.C.A.; Faria,R.O.; Mello,J.R.B.; Hubner,S.O.; Lima,M.; Fischer,G.. |
| ABSTRACT In this study, we described the antifungal activity of three Brazilian propolis extracts: brown, green and from jataí bees against Sporothrix brasiliensis. The extracts were obtained from ethanolic extraction and their chemical composition was determined by high-performance liquid chromatography coupled to mass spectrometry. The cellular toxicity was measured in MDBK (Madin-Darby Bovine Kidney) cells and quantified by the MTT assay (3- (4,5 dimethylthiazol-2yl -2,5-diphenyl-2H bromine tetrazolato). For antifungal activity, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were determined by broth microdilution. The results showed that cell toxicity was not observed at lower concentrations (0.097 to 0.39μg/ml)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Zoonosis; Itraconazole; Antifungal resistance; Therapeutic alternative. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000300819 |
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| Waller,S.B.; Madrid,I.M.; Cleff,M.B.; Santin,R.; Freitag,R.A.; Meireles,M.C.A.; Mello,J.R.B.. |
| ABSTRACT Rosmarinus officinalis L. (rosemary) and Origanum vulgare L. (oregano) are known to have antimicrobial properties, but studies on sporotrichosis are scarce. This study aimed to evaluate the anti-Sporothrix spp. activity of essential oils from commercial products and oils extracted from aerial parts of these plants and analyze their chemical constituents. S. schenckii complex and S. brasiliensis (n: 25) isolated from humans, cats, dogs, and environmental soil were tested through M27-A3 guidelines of CLSI with modification for phytotherapics. The essential oils of R. officinalis L. were similar for MIC50 and MFC50 ≤2.25mg/mL for extracted oil; and 4.5mg/mL and 9mg/mL, respectively, for commercial oil. Both products showed MIC90 of 18mg/mL and MFC90... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sporotrichosis; Antifungal resistance; Oregano; Rosemary; Lamiaceae. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000400991 |
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