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| Zhang,Xiaoqing; Ao,Guokun; Wang,Yuewen; Yan,Wei; Wang,Min; Chen,Erfei; Yang,Fangfang; Yang,Jin. |
| In this report, we describe combined polymorphisms of the UGT1A9, UGT1A7 and UGT1A1 genes in 100 unrelated, healthy Chinese Han subjects. The functional regions of these genes were sequenced and comprehensively analyzed for genetic polymorphisms. Thirty variants were detected, including five novel forms. Tentative functional predictions indicated that a Cys → Arg substitution at position 277 in the UGT1A7 gene could alter the protein conformation and that 12460T > G in the 3'UTR might influence protein translation through specifically expressed miRNAs. UGT1A9*1b was a major functional variant in the subjects examined whereas the *1f allele had a frequency of only 0.5%. A special functional haplotype (GAGAAC) was identified for UGT1A9, 1A7 and 1A1. These... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chinese Han; Genetic polymorphisms; Haplotype; UGT1A. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300008 |
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| Qiao,Junyi; Tan,Zhiliang; Wang,Min. |
| Enteric methane (CH4) emissions in ruminants have attracted considerable attention due to their impact on greenhouse gases and the contribution of agricultural practices to global warming. Over the last two decades, a number of approaches have been adopted to mitigate CH4 emissions. However, the mechanisms of methanogenesis have still not been fully defined. According to the genome sequences of M. ruminantium in the rumen and of M. AbM4 in the abomasum, the pathways of carbon dioxide (CO2) reduction and formate oxidation to CH4 have now been authenticated in ruminants. Furthermore, in the light of species or genera description of methanogens, the precursors of methanogenesis discovered in the rumen and research advances in related subjects, pathways of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Methanogenesis; Carbon dioxide; Formate; Acetate; Methanol. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162014000500013 |
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| Sun,Jing; Hu,Li-Fen; Wang,Min; Shi,Wei; Xu,Xi-Hai; Cheng,Jun; Ma,Tai; Luo,Xiao-Ming; Wang,Zhong-Xin; Ye,Ying; Li,Jia-Bin. |
| Tipo: Info:eu-repo/semantics/other |
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| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100023 |
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| Zhou,Huiqin; Du,Hong; Zhang,Haifang; Shen,Haiying; Yan,Ruhong; He,Yun; Wang,Min; Zhu,Xueming. |
| Staphylococcus aureus (S. aureus) is an important human pathogen, which commonly causes the acquired infectious diseases in the hospital and community. Effective and simple antibiotic treatment against S. aureus-related disease becomes increasingly difficult. Developing a safe and effective vaccine against S. aureus has become one of the world's hot spots once again. The key issue of developing the vaccine of S. aureus is how to find an ideal key pathogenic gene of S. aureus. It was previously suggested that EsxA might be a very important factor in S. aureus abscess formation in mice, but clinical experimental evidence was lacking. We therefore expressed EsxA protein through prokaryotic expression system and purified EsxA protein by Ni-affinity... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: S. aureus; EsxA; Anti-EsxA antibodies; Multi-drug resistant. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000100038 |
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