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	Provedor de dados BJMBR (8) Autor Wang,W. (8) Li,M. (2) Liu,Y.J. (2) Ma,W.H. (2) Zhang,Y.Z. (2) Deng,S.L. (1) Ding,Q. (1) Duan,X-Y. (1) Feng,B. (1) Guo,Y-M. (1) Jiang,C.S. (1) Jiang,H. (1) Li,D.Z. (1) Li,X. (1) Li,Y. (1) Liu,G. (1) Peng,H-M. (1) Qi,X.L. (1) Tang,R. (1) Tang,Z.Y. (1) Mais... Palavra-chave 18F-FDG PET/CT (1) All-cause death rate (1) Amyotrophic lateral sclerosis (1) Biocompatibility (1) Biodegradable (1) Bladder cancer (1) Bone morphogenetic protein (1) C282Y (1) Cardiovascular death rate (1) Chronic kidney disease (1) Chronic renal failure (1) Corrosion (1) Gap junction intercellular communication (1) Gastric cancer (1) Gene silencing (1) H63D (1) HFE (1) High-flux hemodialysis (1) Human signaling network (1) Low-flux hemodialysis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (8) Ano 2018 (1) 2016 (1) 2015 (3) 2014 (3) País Brazil (8) Idioma Inglês (8)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 8 Primeira ... 1 ... Última Transduction motif analysis of gastric cancer based on a human signaling network BJMBR Liu,G.; Li,D.Z.; Jiang,C.S.; Wang,W.. To investigate signal regulation models of gastric cancer, databases and literature were used to construct the signaling network in humans. Topological characteristics of the network were analyzed by CytoScape. After marking gastric cancer-related genes extracted from the CancerResource, GeneRIF, and COSMIC databases, the FANMOD software was used for the mining of gastric cancer-related motifs in a network with three vertices. The significant motif difference method was adopted to identify significantly different motifs in the normal and cancer states. Finally, we conducted a series of analyses of the significantly different motifs, including gene ontology, function annotation of genes, and model classification. A human signaling network was constructed,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Significantly different motifs; Human signaling network; Gastric cancer. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000500369 Targeting PPM1D by lentivirus-mediated RNA interference inhibits the tumorigenicity of bladder cancer cells BJMBR Wang,W.; Zhu,H.; Zhang,H.; Zhang,L.; Ding,Q.; Jiang,H.. Protein phosphatase magnesium/manganese-dependent 1D (PPM1D) is a p53-induced phosphatase that functions as a negative regulator of stress response pathways and has oncogenic properties. However, the functional role ofPPM1D in bladder cancer (BC) remains largely unknown. In the present study, lentivirus vectors carrying small hairpin RNA (shRNA) targeting PPM1D were used to explore the effects ofPPM1D knockdown on BC cell proliferation and tumorigenesis. shRNA-mediated knockdown of PPM1D significantly inhibited cell growth and colony forming ability in the BC cell lines 5637 and T24. Flow cytometric analysis showed that PPM1D silencing increased the proportion of cells in the G0/G1 phase. Downregulation of PPM1Dalso inhibited 5637 cell tumorigenicity in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Protein phosphatase magnesium/manganese-dependent 1D; Bladder cancer; Gene silencing; RNA interference; Proliferation. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014001201044 Mutations in the HFE gene and sporadic amyotrophic lateral sclerosis risk: a meta-analysis of observational studies BJMBR Li,M.; Wang,L.; Wang,W.; Qi,X.L.; Tang,Z.Y.. Iron homeostasis dysregulation has been regarded as an important mechanism in neurodegenerative diseases. The H63D and C282Y polymorphisms in theHFE gene may be involved in the development of sporadic amyotrophic lateral sclerosis (ALS) through the disruption of iron homeostasis. However, studies investigating the relationship between ALS and these two polymorphisms have yielded contradictory outcomes. We performed a meta-analysis to assess the roles of the H63D and C282Y polymorphisms of HFEin ALS susceptibility. PubMed, MEDLINE, EMBASE, and Cochrane Library databases were systematically searched to identify relevant studies. Strict selection criteria and exclusion criteria were applied. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Amyotrophic lateral sclerosis; HFE; C282Y; H63D; Polymorphism; Meta-analysis. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300215 Predictive significance of standardized uptake value parameters of FDG-PET in patients with non-small cell lung carcinoma BJMBR Duan,X-Y.; Wang,W.; Li,M.; Li,Y.; Guo,Y-M.. 18F-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is widely used to diagnose and stage non-small cell lung cancer (NSCLC). The aim of this retrospective study was to evaluate the predictive ability of different FDG standardized uptake values (SUVs) in 74 patients with newly diagnosed NSCLC. 18F-FDG PET/CT scans were performed and different SUV parameters (SUVmax, SUVavg, SUVT/L, and SUVT/A) obtained, and their relationship with clinical characteristics were investigated. Meanwhile, correlation and multiple stepwise regression analyses were performed to determine the primary predictor of SUVs for NSCLC. Age, gender, and tumor size significantly affected SUV parameters. The mean SUVs of squamous cell carcinoma were... Tipo: Info:eu-repo/semantics/article Palavras-chave: 18F-FDG PET/CT; Standardized uptake value (SUV); Prediction; Non-small cell lung cancer. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000300267 Improved biological performance of magnesium by micro-arc oxidation BJMBR Ma,W.H.; Liu,Y.J.; Wang,W.; Zhang,Y.Z.. Magnesium and its alloys have recently been used in the development of lightweight, biodegradable implant materials. However, the corrosion properties of magnesium limit its clinical application. The purpose of this study was to comprehensively evaluate the degradation behavior and biomechanical properties of magnesium materials treated with micro-arc oxidation (MAO), which is a new promising surface treatment for developing corrosion resistance in magnesium, and to provide a theoretical basis for its further optimization and clinical application. The degradation behavior of MAO-treated magnesium was studied systematically by immersion and electrochemical tests, and its biomechanical performance when exposed to simulated body fluids was evaluated by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Magnesium; Micro-arc oxidation; Biodegradable; Biocompatibility; Mechanical properties; Corrosion. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000300214 Prognostic effect of high-flux hemodialysis in patients with chronic kidney disease BJMBR Li,X.; Xu,H.; Xiao,X.C.; Deng,S.L.; Wang,W.; Tang,R.. We investigated the prognostic effects of high-flux hemodialysis (HFHD) and low-flux hemodialysis (LFHD) in patients with chronic kidney disease (CKD). Both an electronic and a manual search were performed based on our rigorous inclusion and exclusion criteria to retrieve high-quality, relevant clinical studies from various scientific literature databases. Comprehensive meta-analysis 2.0 (CMA 2.0) was used for the quantitative analysis. We initially retrieved 227 studies from the database search. Following a multi-step screening process, eight high-quality studies were selected for our meta-analysis. These eight studies included 4967 patients with CKD (2416 patients in the HFHD group, 2551 patients in the LFHD group). The results of our meta-analysis... Tipo: Info:eu-repo/semantics/article Palavras-chave: High-flux hemodialysis; Low-flux hemodialysis; Chronic kidney disease; Chronic renal failure; All-cause death rate; Cardiovascular death rate. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000100706 Effectiveness of preoperative decolonization with nasal povidone iodine in Chinese patients undergoing elective orthopedic surgery: a prospective cross-sectional study BJMBR Peng,H-M.; Wang,L-C.; Zhai,J-L.; Weng,X-S.; Feng,B.; Wang,W.. Staphylococcus aureus colonization in the nares of patients undergoing elective orthopedic surgery increases the potential risk of surgical site infections. Methicillin-resistant S. aureus (MRSA) has gained recognition as a pathogen that is no longer only just a hospital-acquired pathogen. Patients positive for MRSA are associated with higher rates of morbidity and mortality following infection. MRSA is commonly found in the nares, and methicillin-sensitive S. aureus (MSSA) is even more prevalent. Recently, studies have determined that screening for this pathogen prior to surgery and diminishing staphylococcal infections at the surgical site will dramatically reduce surgical site infections. A nasal mupirocin treatment is shown to significantly reduce the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nasal methicillin-resistant; Staphylococcus aureus; Orthopedic surgery; Nasal povidone iodine; Prospective cross-sectional study. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200615 Neuropeptide Y, substance P, and human bone morphogenetic protein 2 stimulate human osteoblast osteogenic activity by enhancing gap junction intercellular communication BJMBR Ma,W.H.; Liu,Y.J.; Wang,W.; Zhang,Y.Z.. Bone homeostasis seems to be controlled by delicate and subtle “cross talk” between the nervous system and “osteo-neuromediators” that control bone remodeling. The purpose of this study was to evaluate the effect of interactions between neuropeptides and human bone morphogenetic protein 2 (hBMP2) on human osteoblasts. We also investigated the effects of neuropeptides and hBMP2 on gap junction intercellular communication (GJIC). Osteoblasts were treated with neuropeptide Y (NPY), substance P (SP), or hBMP2 at three concentrations. At various intervals after treatment, cell viability was measured by the MTT assay. In addition, cellular alkaline phosphatase (ALP) activity and osteocalcin were determined by colorimetric assay and radioimmunoassay,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Neuropeptide; Bone morphogenetic protein; Osteoblast; Gap junction intercellular communication. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000400299 Registros recuperados: 8 Primeira ... 1 ... Última

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