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Artificial neural network models for predicting 1-year mortality in elderly patients with intertrochanteric fractures in China BJMBR
Shi,L.; Wang,X.C.; Wang,Y.S..
The mortality rate of older patients with intertrochanteric fractures has been increasing with the aging of populations in China. The purpose of this study was: 1) to develop an artificial neural network (ANN) using clinical information to predict the 1-year mortality of elderly patients with intertrochanteric fractures, and 2) to compare the ANN's predictive ability with that of logistic regression models. The ANN model was tested against actual outcomes of an intertrochanteric femoral fracture database in China. The ANN model was generated with eight clinical inputs and a single output. ANN's performance was compared with a logistic regression model created with the same inputs in terms of accuracy, sensitivity, specificity, and discriminability. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Artificial neural network; Intertrochanteric fracture; Outcome prediction; One-year mortality.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001100993
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Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A BJMBR
Wan,Y.; Tang,M.H.; Chen,X.C.; Chen,L.J.; Wei,Y.Q.; Wang,Y.S..
Immune response plays an important role in the development of hepatic fibrosis. In the present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis induced by immunological mechanism. In the acute hepatitis model, quercetin (2.5 mg/kg) was injected iv into mice 30 min after concanavalin A (Con A) challenge. Mice were sacrificed 4 or 24 h after Con A injection, and aminotransferase tests and histopathological sections were performed. Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Consistent with this observation, treatment with quercetin markedly attenuated the pathologic changes in the liver. A hepatic fibrosis model was also generated in mice...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Quercetin; Concanavalin A; Acute hepatitis; Hepatic fibrosis; Liposome.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000800655
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