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| Zhao,Yanyin; Liu,Bingyou; Wang,Yi; Xiao,Baoguo. |
| This study aimed to investigate the therapeutic effect of fasudil on treating experimental autoimmune neuritis (EAN). Twenty-four EAN mice were randomly assigned to fasudil treatment (Fasudil group) or saline treatment (EAN model group) for 28 days. Clinical symptom score was evaluated every other day; inflammatory cell infiltration, demyelination, anti-myelin basic protein (MBP), inflammatory cytokines, inducible nitric oxide synthase (iNOS), and arginase-1 were detected in sciatic nerves at day 28. Th1, Th2, Th17, and Tregs proportions in splenocytes were detected at day 28. Clinical symptom score was found to be attenuated in the Fasudil group compared to the EAN model group from day 12 to day 28. Sciatic nerve inflammatory cell counts by HE staining... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fasudil; Experimental autoimmune neuritis; Th1; Th17; Tregs; M2 macrophages polarization. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000100607 |
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| Xie,Quan; Kang,Houyang; Sparkes,Debbie Louise; Tao,Shan; Hu,Zhiqin; Xu,Lili; Fan,Xing; Sha,Lina; Zhang,Haiqin; Wang,Yi; Zeng,Jian; Zhou,Yonghong. |
| English grain aphid (EGA, Sitobion avenae Fabricius) is an important pest in wheat (Triticum aestivum L.). To develop EGA-resistant varieties, introducing the desirable genes from related species is regarded as an efficient avenue. In this study, the F1, F2 and F3 plants derived from the cross of EGA-susceptible wheat-Psathyrostachys huashanica Keng ex Kuo amphiploid (PHW-SA, AABBDDNsNs) and EGA-resistant triticale (Zhongsi 828, AABBRR) were analyzed for EGA resistance. Consequently, PHW-SA was moderately susceptible while Zhongsi 828 and their F1 hybrids were immune, suggesting that the resistance is dominant. All the F2 plants showed high resistance or immunity over two years, indicating that EGA resistance genes are more likely carried by the rye... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chromosome constitutions; Genetic resources; Wide cross. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162013000300004 |
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