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	Provedor de dados BJPS (1) Autor Araujo,Bibiana Verlindo de (1) Cordenonsi,Leticia Malgarim (1) Sponchiado,Rafaela Martins (1) Volpato,Nadia Maria (1) Wingert,Nathalie Ribeiro (1) Palavra-chave Acyclovir/pharmaceutical equivalence. (1) Acyclovir/semisolid formulations (1) Acyclovir/skin penetration/in vitro studies (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2016 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última In vitro evaluation of cutaneous penetration of acyclovir from semisolid commercial formulations and relation with its effective antiviral concentration BJPS Sponchiado,Rafaela Martins; Cordenonsi,Leticia Malgarim; Wingert,Nathalie Ribeiro; Araujo,Bibiana Verlindo de; Volpato,Nadia Maria. ABSTRACT The evaluation of drug permeation/penetration of semisolid formulations into animal skin can be useful to supplement the pharmaceutical equivalence. This paper describes the in vitro assessment of acyclovir (ACV) into porcine skin from commercial formulations with etermination of drug concentration in different layers of cutaneous tissue to correlate with effective antiviral concentration in order to improve the equivalence decision. Studies were conducted using Franz cells and porcine skin. Selected pharmaceutical creams containing ACV had identical (reference and generic) and different (similar) excipients. A software program was employed for the simulation of antiviral effectiveness in the skin. Regarding ACV skin penetration, the first batch... Tipo: Info:eu-repo/semantics/article Palavras-chave: Acyclovir/skin penetration/in vitro studies; Acyclovir/semisolid formulations; Acyclovir/pharmaceutical equivalence.. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000300483 Registros recuperados: 1 Primeira ... 1 ... Última

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