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| Geng,Wenjia; Wei,Ribao; Liu,Shuwen; Tang,Li; Zhu,Hanyu; Chen,Pu; Wu,Jie; Zhang,Xueguang; Zhu,Fei; Yin,Zhong; Chen,Xiangmei. |
| BACKGROUND: In China, mesangial proliferative glomerulonephritis (MsPGN) is one of the most common kidney diseases. In this study, we treated a rat model of chronic anti-Thy-1 MsPGN with Shenhua Tablet and evaluated whether the tablet was able to protect the kidney function. Thirty-six Wistar rats were randomly divided into six groups: (1) Sham surgery (Sham); (2) anti-Thy-1 nephritis model (Thy-1); (3) anti-Thy-1 nephritis model + irbesartan-treated (Irb); (4) anti-Thy-1 nephritis model + low-dose of Shenhua Tablet (SHL); (5) anti-Thy-1 nephritis model + medium-dose of Shenhua Tablet (SHM); (6) anti-Thy-1 nephritis model + high-dose of Shenhua Tablet (SHH RESULTS: Thirteen weeks after drug treatment, urinary proteins were quantified and renal pathological... |
| Tipo: Journal article |
Palavras-chave: Shenhua Tablet; Chronic anti-Thy-1 glomerulonephritis; Mesangial cell proliferation; Erk. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100017 |
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