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| Shi,Luye; Jiang,Mengwan; Li,Mengyang; Shang,Xiaozhen; Li,Xiujuan; Huang,Maolin; Wu,Yue; Qiao,Congcong; Wang,Xinrui; Tian,Xiangyu; Shi,Yuhua; Wang,Zhenlong. |
| ABSTRACT The response mechanism and interaction patterns of HIF-1α and p53 in animals in an hypoxic environment are crucial for their hypoxic tolerance and adaptation. Many studies have shown that underground rodents have better hypoxic adaptation characteristics. However, the mechanism by which HIF-1α and p53 in underground rodents respond to hypoxic environments compared with in ground rodents remains unclear. Further, whether a synergy between HIF-1α and p53 enables animals tolerate extremely hypoxic environments is unclear. We studied HIF-1α and p53 expression in the brain tissue and cell apoptosis in the hippocampal CA1 region during 6 hours of acute hypoxia (5% oxygen) in Lasiopodomys mandarinus (Milne-Edwards, 1871) and Lasiopodomys brandtii (Radde,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Comparative biology; Hippocampal CA1 region; Oxygen; Subterranean rodents. |
| Ano: 2021 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-46702021000100305 |
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| Li,Bolin; Ma,Honglan; Guo,Huihui; Liu,Peng; Wu,Yue; Fan,Lihong; Cao,Yumeng; Jian,Zhijie; Sun,Chaofeng; Li,Hongbing. |
| Left atrial diameter (LAD) has been considered an independent risk factor for atrial fibrillation (AF) relapse after pulmonary vein isolation (PVI). However, whether LAD or other factors are more predictive of late recurrence in patients with paroxysmal AF remains unclear. We aimed to evaluate the value of pulmonary vein (PV) parameters for predicting AF relapse 1 year after patients underwent cryoablation for paroxysmal AF. Ninety-seven patients with paroxysmal AF who underwent PVI successfully were included. PV parameters were measured through computed tomography scans prior to PVI. A total of 28 patients had recurrence of AF at one-year follow-up. The impact of several variables on recurrence was evaluated in multivariate analyses. LAD and the time from... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Atrial fibrillation; Cryoablation; Right inferior pulmonary vein; Pulmonary vein parameter. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000900610 |
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