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| Xiang,Yu-luan; He,Li; Xiao,Jun; Xia,Shuang; Deng,Song-bai; Xiu,Yun; She,Qiang. |
| Cardiovascular complications are a leading cause of mortality in patients with diabetes mellitus (DM). The present study was designed to investigate the effects of trimetazidine (TMZ), an anti-angina drug, on transient outward potassium current (Ito) remodeling in ventricular myocytes and the plasma contents of free fatty acid (FFA) and glucose in DM. Sprague-Dawley rats, 8 weeks old and weighing 200-250 g, were randomly divided into three groups of 20 animals each. The control group was injected with vehicle (1 mM citrate buffer), the DM group was injected with 65 mg/kg streptozotocin (STZ) for induction of type 1 DM, and the DM + TMZ group was injected with the same dose of STZ followed by a 4-week treatment with TMZ (60 mg·kg-1·day-1). All animals were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Transient outward K+ current; Free fatty acid; Trimetazidine; Diabetic cardiomyopathy; Channel protein; Ventricular myocytes. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300004 |
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