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| Chen,Kai; Wu,Dajiang; Zhu,Xiaodong; Ni,Haijian; Wei,Xianzhao; Mao,Ningfang; Xie,Yang; Niu,Yunfei; Li,Ming. |
| In this study, we used microarray analysis to investigate the biogenesis and progression of intervertebral disc degeneration. The gene expression profiles of 37 disc tissue samples obtained from patients with herniated discs and degenerative disc disease collected by the National Cancer Institute Cooperative Tissue Network were analyzed. Differentially expressed genes between more and less degenerated discs were identified by significant analysis of microarray. A total of 555 genes were significantly overexpressed in more degenerated discs with a false discovery rate of < 3%. Functional annotation showed that these genes were significantly associated with membrane-bound vesicles, calcium ion binding and extracellular matrix. Protein-protein interaction... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genes; Intervertebral disc degeneration; Molecular classification; Protein-protein interaction. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300021 |
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