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| Xu,Liang; Tao,Xiaojun; Gao,Yucong; Zhang,Wenjie; Meng,Yihan; Li,Cuiyu; Jiang,Mingyue; Xixiang,Ying. |
| ABSTRACT Hydroxydihydrobovolide (HDB) was for the first time isolated from Portulaca oleracea L. and then its cytotoxicity against SH-SYTY cells was studied. Moreover, a rapid and sensitive ultra-high performance liquid chromatographic (UHPLC) method with bergapten as internal standard (IS) was developed and validated to investigate the pharmacokinetics of HDB in rats after intravenous and oral administrations of extract (POE). The UHPLC analysis was performed on a Diamonsil C18 analytical column, using acetonitrile-water (35:65, v/v) as the mobile phase with UV detection at 220 nm. The calibration curve was linear over the range of 0.2-25 µg/mL in rat plasma. The average extraction recovery was from 90.1 to 98.9%, and the relative standard deviations... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portulaca oleracea L./hydroxydihydrobovolide; Portulaca oleracea L./hydroxydihydrobovolide/cytotoxicity; Portulaca oleracea L./hydroxydihydrobovolide/pharmacokinetics; Hydroxydihydrobovolide/Ultra-high performance liquid chromatography. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200615 |
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