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	Provedor de dados Biol. Res. (1) Genet. Mol. Biol. (1) Autor Xu,Cun-Shuan (2) Chen,Xiao-Guang (1) Wang,Gai-Ping (1) Palavra-chave Partial hepatectomy (2) DNA repair genes (1) Liver regeneration (1) MALDI TOF/TOF MS (1) Proteomic (1) Rat genome array (1) Rat liver regeneration (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Journal article (1) Ano 2014 (1) 2011 (1) País Brazil (1) Chile (1) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Alterations in DNA repair gene expression and their possible regulation in rat-liver regeneration Genet. Mol. Biol. Wang,Gai-Ping; Xu,Cun-Shuan. Rapidly proliferating tissue may require enhanced DNA repair capacity in order to avoid fixation of promutagenic DNA lesions to mutations. Partial hepatectomy (PH) triggers cell proliferation during liver regeneration (LR). However, little is known on how DNA repair genes change and how they are regulated at the transcriptional level during LR. In the present study, the Rat Genome 230 2.0 array was used to detect the expression profiles of DNA repair genes during LR, and differential expression of selected genes was confirmed by real-time RT-PCR. 69 DNA repair genes were found to be associated with LR, more than half of which distributed in a cluster characterized by a gradual increase at 24-72h and then returning to normal. The expression of base excision... Tipo: Info:eu-repo/semantics/article Palavras-chave: Partial hepatectomy; Rat genome array; DNA repair genes; Liver regeneration. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200023 Proteomic analysis of the regenerating liver following 2/3 partial hepatectomy in rats Biol. Res. Chen,Xiao-Guang; Xu,Cun-Shuan. BACKGROUND: Liver regeneration (LR) after 2/3 partial hepatectomy (PH) is one of the most studied models of cell, organ, and tissue regeneration. Although the transcriptional profile analysis of regenerating liver has been carried out by many reserachers, the dynamic protein expression profile during LR has been rarely reported up to date. Therefore, this study aims to detect the global proteomic profile of the regenerating rat liver following 2/3 hepatectomy, thereby gaining some insights into hepatic regeneration mechanism. RESULTS: Protein samples extracted from the sham-operated and the regenerating rat livers at 6, 12, 24, 72, 120 and 168 h after PH were separated by IEF/SDS-PAGE and then analyzed by MALDI-TOF/TOF mass spectrometry. Compared to... Tipo: Journal article Palavras-chave: Partial hepatectomy; Rat liver regeneration; Proteomic; MALDI TOF/TOF MS. Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100053 Registros recuperados: 2 Primeira ... 1 ... Última

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