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CTLA4 enhances the osteogenic differentiation of allogeneic human mesenchymal stem cells in a model of immune activation BJMBR
Dai,F.; Zhang,F.; Sun,D.; Zhang,Z.H.; Dong,S.W.; Xu,J.Z..
Allogeneic mesenchymal stem cells (allo-MSCs) have recently garnered increasing interest for their broad clinical therapy applications. Despite this, many studies have shown that allo-MSCs are associated with a high rate of graft rejection unless immunosuppressive therapy is administered to control allo-immune responses. Cytotoxic T-lymphocyte-associated protein 4 (CTLA4) is a co-inhibitory molecule expressed on T cells that mediates the inhibition of T-cell function. Here, we investigated the osteogenic differentiation potency of allo-MSCs in an activated immune system that mimics the in vivo allo-MSC grafting microenvironment and explored the immunomodulatory role of the helper T cell receptor CTLA4 in this process. We found that MSC osteogenic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: CTLA4; Mesenchymal stem cells; Immunomodulatory; Bone tissue engineering.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000700629
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