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| Qu,Gonglin; Xu,Liang; Zhang,Wenjie; Ying,Xixiang. |
| The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (62:38, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portulaca oleracea L./Oleracimine; Ultra-High-Performance Liquid Chromatography/Rat plasma; Pharmacokinetics. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400611 |
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| Xu,Liang; Tao,Xiaojun; Gao,Yucong; Zhang,Wenjie; Meng,Yihan; Li,Cuiyu; Jiang,Mingyue; Xixiang,Ying. |
| ABSTRACT Hydroxydihydrobovolide (HDB) was for the first time isolated from Portulaca oleracea L. and then its cytotoxicity against SH-SYTY cells was studied. Moreover, a rapid and sensitive ultra-high performance liquid chromatographic (UHPLC) method with bergapten as internal standard (IS) was developed and validated to investigate the pharmacokinetics of HDB in rats after intravenous and oral administrations of extract (POE). The UHPLC analysis was performed on a Diamonsil C18 analytical column, using acetonitrile-water (35:65, v/v) as the mobile phase with UV detection at 220 nm. The calibration curve was linear over the range of 0.2-25 µg/mL in rat plasma. The average extraction recovery was from 90.1 to 98.9%, and the relative standard deviations... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Portulaca oleracea L./hydroxydihydrobovolide; Portulaca oleracea L./hydroxydihydrobovolide/cytotoxicity; Portulaca oleracea L./hydroxydihydrobovolide/pharmacokinetics; Hydroxydihydrobovolide/Ultra-high performance liquid chromatography. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200615 |
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