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| Zhang,Wei; Lv,Shengqing; Liu,Jun; Zang,Zhenle; Yin,Junyi; An,Ning; Yang,Hui; Song,Yechun. |
| PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrations of PCI-24781 (0, 0.25, 0.5, 1, 2.5 and 5 M) and analyzed for cell proliferation by the MTS 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay and colony formation, and cell cycle and apoptosis were assessed by flow cytometry. The expression of EZH2 and apoptosis-related proteins was assessed by western blotting. Malignant glioma cells were also transfected with EZH2 siRNA to examine how PCI-24781 suppresses tumor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: EZH2; Malignant gliomas; PCI-24781; PIK3K/Akt/mTOR signaling pathway. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000500015 |
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| Yang,Yan; Yang,Hui; Pan,Hongyin; Xu,Jue; Hu,Tao. |
| Alveolar bone dehiscences, which were "V" shaped defects related the margin of the alveolar bone, were common findings in different populations and decreased bony support of teeth. It was difficult to detect dehiscence during direct clinical examination. All of the previous studies on the prevalence of dehiscences were based on dry human skulls. In the current article, we evaluated the prevalence of dehiscences occurring naturally in a Chinese subpopulation, and prepared a classification of dehiscences using cone-beam computed tomography (CBCT). The high prevalence rate of dehiscences and different characteristics of each category suggest that it would be helpful for clinicians who perform periodontal surgery, endodontic surgery, implant surgery or... |
| Tipo: Journal article |
Palavras-chave: Alveolar bone loss; Periodontal disease; Cone-beam computed tomography; Oral surgery; Pérdida de hueso alveolar; Enfermedad periodontal; Tomografía computadorizada de haz cónico; Cirugía oral. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000100057 |
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| Yang,Hui; Zhang,Weiru; Xie,Tingting; Wang,Xuan; Ning,Wangbin. |
| This study aimed to investigate the mechanism of fluorofenidone (AKF-PD) in treating renal interstitial fibrosis in rats with unilateral urinary obstruction (UUO). Thirty-two male Sprague-Dawley rats were randomly divided into sham, UUO, UUO + enalapril, and UUO + AKF-PD groups. All rats, except sham, underwent left urethral obstruction surgery to establish the animal model. Rats were sacrificed 14 days after surgery, and serum was collected for renal function examination. Kidneys were collected to observe pathological changes. Immunohistochemistry was performed to assess collagen I (Col I) protein expression, and terminal deoxynucleotidyl transferase-mediated nick end-labeling staining to observe the apoptosis of renal tubular epithelial cells. The... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fluorofenidone; Unilateral ureteral obstruction; Renal fibrosis; Apoptosis; Enalapril. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001100604 |
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