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	Provedor de dados BJMBR (1) Autor Chen,C. (1) Yang,R.L. (1) Palavra-chave 3′-dimethylallyloxy)-5-methyl-6-methoxyphthalide] p73 Apoptosis (1) MP [4-(3′ (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última A phthalide derivative isolated from endophytic fungiPestalotiopsis photiniae induces G1 cell cycle arrest and apoptosis in human HeLa cells BJMBR Chen,C.; Yang,R.L.. MP [4-(3′,3′-dimethylallyloxy)-5-methyl-6-methoxyphthalide] was obtained from liquid culture of Pestalotiopsis photiniaeisolated from the Chinese Podocarpaceae plant Podocarpus macrophyllus. MP significantly inhibited the proliferation of HeLa tumor cell lines. After treatment with MP, characteristic apoptotic features such as DNA fragmentation and chromatin condensation were observed in DAPI-stained HeLa cells. Flow cytometry showed that MP induced G1 cell cycle arrest and apoptosis in a dose-dependent manner. Western blotting and real-time reverse transcription-polymerase chain reaction were used to investigate protein and mRNA expression. MP caused significant cell cycle arrest by upregulating the cyclin-dependent kinase inhibitor p27KIP1 protein and... Tipo: Info:eu-repo/semantics/article Palavras-chave: MP [4-(3′; 3′-dimethylallyloxy)-5-methyl-6-methoxyphthalide] p73 Apoptosis. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000800643 Registros recuperados: 1 Primeira ... 1 ... Última

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