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	Provedor de dados BABT (1) BJMBR (1) Autor Yang,Ying (2) Deng,Guanjun (1) Huang,Shengwei (1) Liu,Zhuogang (1) Wei,Minjie (1) Wu,Lifang (1) Wu,Zhengyan (1) Yan,Wei (1) Mais... Palavra-chave Cellulolytic bacteria (1) Effects of Metal ions (1) Multiple myeloma (1) P27 (1) Response surface methodology (1) SKPin C1 (1) Scarab larvae (1) Skp2 (1) Thermotolerant cellulases (1) Ubiquitination (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2015 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Optimization of Endoglucanase Production from a Novel Bacterial Isolate, Arthrobacter sp. HPG166 and Characterization of Its Properties BABT Huang,Shengwei; Deng,Guanjun; Yang,Ying; Wu,Zhengyan; Wu,Lifang. ABSTRACTIn this study, a potential novel cellulolytic bacteriumArthrobacter sp. HPG166 was isolated from the hindgut of root-feeding larvaeHolotrichia parallela. Optimization of fermentation factors for endoglucanase production byArthrobacter sp. HPG166 was carried out via response surface methodology. Sodium carboxymethylcellulose 1.19% (w/v) and beef extract 0.35% (w/v) were the ideal combination of carbon and nitrogen sources for enzyme production; the optimum temperature and pH for cellulase production were 34°C and pH 8.0 respectively. Under the optimized fermentation conditions, the maximum endoglucanase activity of 1.411 U mL-1 was obtained. The crude endoglucanase was thermotolerant as it retained 50.31% of its activity after incubation at 70°C for... Tipo: Info:eu-repo/semantics/article Palavras-chave: Scarab larvae; Cellulolytic bacteria; Response surface methodology; Thermotolerant cellulases; Effects of Metal ions. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000500692 Skp2 inhibitor SKPin C1 decreased viability and proliferation of multiple myeloma cells and induced apoptosis BJMBR Yang,Ying; Yan,Wei; Liu,Zhuogang; Wei,Minjie. Multiple myeloma (MM) is a malignant neoplasm of plasma, and exhibits several harmful effects including osteolytic injuries, hypercalcemia, and immune dysfunction. Many patients with MM succumb to the underlying malignancy. An S-phase kinase-related protein 2 (Skp2) inhibitor, designated SKPin C1, has been developed and confirmed to have an inhibitory effect on metastatic melanoma cells. This study aimed to determine the effect of SKPin C1 on MM. Normal B lymphocytes, THP-1 cells, and MM U266 and RPMI 8226 cells were exposed to various dosages of SKPin C1 for 48 h. Cell proliferation was determined by MTT, EdU staining, and cell cycle assays. Western blot assays were performed to assess intracellular protein levels of Skp2, p27, and cleaved caspase-3. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Skp2; SKPin C1; Multiple myeloma; P27; Ubiquitination. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500605 Registros recuperados: 2 Primeira ... 1 ... Última

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