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Effects of sedation during upper gastrointestinal endoscopy on endocrine response and cardiorespiratory function BJMBR
Yetkin,G.; Oba,S.; Uludag,M.; Paksoy,I.; Akgün,I.; Eren,N..
Upper gastrointestinal endoscopy is often accompanied by tachycardia which is known to be an important pathogenic factor in the development of myocardial ischemia. The pathogenesis of tachycardia is unknown but the condition is thought to be due to the endocrine response to endoscopy. The purpose of the present study was to investigate the effects of sedation on the endocrine response and cardiorespiratory function. Forty patients scheduled for diagnostic upper gastrointestinal endoscopy were randomized into 2 groups. While the patients in the first group did not receive sedation during upper gastrointestinal endoscopy, the patients in the second group were sedated with intravenous midazolam at the dose of 5 mg for those under 65 years or 2.5 mg for those...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Stress response; Oxygen saturation; Sedation; Upper gastrointestinal endoscopy; Tachycardia.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200008
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Changes in NAD/ADP-ribose metabolism in rectal cancer BJMBR
Yalcintepe,L.; Turker-Sener,L.; Sener,A.; Yetkin,G.; Tiryaki,D.; Bermek,E..
The extent of ADP-ribosylation in rectal cancer was compared to that of the corresponding normal rectal tissue. Twenty rectal tissue fragments were collected during surgery from patients diagnosed as having rectal cancer on the basis of pathology results. The levels of ADP-ribosylation in rectum cancer tissue samples (95.9 ± 22.1 nmol/ml) was significantly higher than in normal tissues (11.4 ± 4 nmol/ml). The level of NAD+ glycohydrolase and ADP-ribosyl cyclase activities in rectal cancer and normal tissue samples were measured. Cancer tissues had significantly higher NAD+ glycohydrolase and ADP-ribosyl cyclase activities than the control tissues (43.3 ± 9.1 vs 29.2 ± 5.2 and 6.2 ± 1.6 vs 1.6 ± 0.4 nmol mg-1 min-1). Approximately 75% of the NAD+...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rectal cancer; ADP-ribosylation; NAD+; NAD+ glycohydrolase; Poly(ADP-ribose) polymerase.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000300006
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