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	Provedor de dados BJMBR (1) Autor Hua-Hong,Wang (1) Jun-Xia,Li (1) Xin-Guang,Liu (1) Yan,Chi (1) Yi-Xuan,Li (1) Palavra-chave 5-Hydroxytryptamine receptor (1) SERT expression (1) Serotonin (1) Serotonin transport protein (1) Visceral hypersensitivity (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Effect of the 5-HT4 receptor and serotonin transporter on visceral hypersensitivity in rats BJMBR Yan,Chi; Xin-Guang,Liu; Hua-Hong,Wang; Jun-Xia,Li; Yi-Xuan,Li. Visceral hypersensitivity plays an important role in motor and sensory abnormalities associated with irritable bowel syndrome, but the underlying mechanisms are not fully understood. The present study was designed to evaluate the expression of the 5-HT4 receptor and the serotonin transporter (SERT) as well as their roles in chronic visceral hypersensitivity using a rat model. Neonatal male Sprague-Dawley rats received intracolonic injections of 0.5% acetic acid (0.3-0.5 mL at different times) between postnatal days 8 and 21 to establish an animal model of visceral hypersensitivity. On day 43, the threshold intensity for a visually identifiable contraction of the abdominal wall and body arching were recorded during rectal distention. Histological evaluation... Tipo: Info:eu-repo/semantics/article Palavras-chave: 5-Hydroxytryptamine receptor; Serotonin; Serotonin transport protein; Visceral hypersensitivity; SERT expression. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000010 Registros recuperados: 1 Primeira ... 1 ... Última

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